Njira yatsopano yochizira rosacea pogwiritsa ntchito ukadaulo wabwino kwambiri wa pulse: In vivo ndi maphunziro azachipatala

Mbiri:Rosacea ndi matenda otupa akhungu omwe amakhudza nkhope, ndipo chithandizo chamakono sichili chokhutiritsa. Kutengera ndi Photomodulation of optimal pulse technology (OPT), tinapanga njira yatsopano yochizira, yomwe ndi, OPT yapamwamba yokhala ndi mphamvu zochepa, ma pulse atatu, komanso kutalika kwa pulse (AOPT-LTL).

Zolinga:Tinali ndi cholinga chofufuza kuthekera ndi njira zoyambira zama cell za chithandizo cha AOPT-LTL mu mtundu wa mbewa ngati rosacea. Kuphatikiza apo, tidawunikanso chitetezo ndi mphamvu kwa odwala omwe ali ndi erythematotelangiectatic rosacea (ETR).

Zida ndi njira:Kusanthula kwa morphological, histological, and immunohistochemical anagwiritsidwa ntchito pofufuza mphamvu ndi njira za chithandizo cha AOPT-LTL mu LL-37-induced rosacea-like mouse model. Komanso, odwala 23 omwe ali ndi ETR adaphatikizidwa ndipo adalandira nthawi zosiyanasiyana za chithandizo pakapita masabata a 2 malingana ndi kuopsa kwa matenda awo. Zotsatira za chithandizo zinayesedwa poyerekezera zithunzi zachipatala kumayambiriro, sabata la 1, ndi miyezi ya 3 pambuyo pa chithandizo, kuphatikizapo mtengo wofiira, GFSS, ndi CEA scores.

Zotsatira:Pambuyo pa chithandizo cha AOPT-LTL cha mbewa, tinawona kuti phenotype yofanana ndi rosacea, kulowetsedwa kwa selo yotupa, ndi zolakwika za mitsempha zinasinthidwa kwambiri, ndipo kufotokozera kwa mamolekyu apakati a rosacea kunaletsedwa kwambiri. Mu kafukufuku wazachipatala, chithandizo cha AOPT-LTL chinapereka zotsatira zokhutiritsa pa erythema komanso kuyaka kwa odwala a ETR. Palibe zovuta zoyipa zomwe zidawonedwa.

Mapeto:AOPT-LTL ndi njira yotetezeka komanso yothandiza pochiza ETR.