Chomwe chimapangitsa kukalamba kwa khungu:
Kuwala kwa UV, kujambula
70% ya ukalamba wa khungu umachokera ku kujambula zithunzi
Kuwala kwa UV kumakhudza collagen m'thupi lathu, zomwe zimapangitsa khungu kukhala laling'ono. Ngati collagen ichepa, khungu lidzakhala lochepa kutha, kugwedezeka, kusasunthika, khungu losagwirizana, hyperpigmentation, pigmentation ndi mavuto ena a khungu.
Kuwala kwa dzuwa kumagawidwa kukhala UVA ndi UVB. Mafunde a UVB ali ndi mafunde afupiafupi ndipo amatha kungowotcha pamwamba pa khungu lathu, osatha kulowa mkati mwa khungu; komabe, kuwala kwa UVA kumakhala ndi kutalika kwakutali ndipo kumatha kulowa mkati mwa galasi ndikuzama pakhungu, pamapeto pake kufooketsa kolajeni ndikupangitsa kukula kwa makwinya.
M'mawu osavuta, UVA imatsogolera ku ukalamba, UVB imatsogolera kuyaka, ndipo kuwala kwa ultraviolet kumatha kuwononga DNA yama cell, kuchepetsa ntchito ya fibroblast, ndipo kaphatikizidwe ka collagen kumatsekedwa, zomwe zimapangitsa kuti ma cell asinthe, kukalamba, ndi apoptosis. Choncho, UV ili paliponse, kaya ndi dzuwa kapena mitambo, muyenera kuchita ntchito yabwino yoteteza dzuwa.
Chinthu chachiwiri chofunika kwambiri pa ukalamba wa khungu
Oxidative ma free radicals
Liwu lofunikira la ma free radicals ndi 'oxygen'. Timapuma pafupifupi 98 mpaka 99 peresenti ya okosijeni nthawi iliyonse tikapuma; amagwiritsidwa ntchito kuwotcha chakudya chomwe timadya ndikutulutsa mamolekyu ang'onoang'ono kuti maselo athu agwire ntchito, ndipo amatulutsa mphamvu zambiri kuti minofu yathu igwire ntchito.
Koma mwina 1% kapena 2% ya okosijeni amasankha njira yosiyana komanso yoopsa, mpweya wochepa uwu, womwe nthawi zambiri umatchedwa ma free radicals, omwe amaukira maselo athu. Pakapita nthawi, kuwonongeka kumeneku kumachulukana pakapita nthawi.
Chodziwika kwambiri ndi zizindikiro za ukalamba zomwe zimawonekera pakhungu. Thupi lathu lili ndi njira yodzitetezera yomwe imakonzanso kuwonongeka kwa maselo athu ndi ma free radicals, koma pamene ma free radicals achulukana mofulumira kuposa momwe maselo a thupi angawakonzere, khungu limakalamba pang'onopang'ono.
Chithunzi pamwambapa ndi khungu lenileni la khungu la thupi lathu, mukhoza kuona bwino kuti pamwamba pa epidermis ndi mdima ndipo dermis pansi ndi yowala pang'ono, dermis ndi kumene timapanga collagen, ndipo maselo omwe amapanga collagen amatchedwa fibroblasts, makina opangira collagen.
Ma fibroblasts omwe ali pakati pa chithunzicho ndi ma fibroblasts, ndipo ukonde wa kangaude wozungulira iwo ndi collagen. Collagen imapangidwa ndi ma fibroblasts, ndipo khungu laling'ono limakhala lamitundu itatu komanso lolumikizana mwamphamvu, pomwe ma fibroblasts amakoka mwamphamvu ulusi wa collagen kuti khungu lachichepere likhale lodzaza komanso losalala.
Ndipo khungu lakale, ma fibroblasts ndi collagen kugwirizana pakati pa kupasuka kwa fibroblasts okalamba nthawi zambiri amakana kulowa kwa collagen, m'kupita kwa nthawi, khungu linayambanso kukalamba, izi ndi zomwe timanena kuti kukalamba kwa khungu, timatani kuti tithetse makutidwe ndi okosijeni. khungu analandira?
Kuwonjezera pa kumvetsera kwambiri zoteteza ku dzuwa, tikhoza kugwiritsa ntchito zina ndi vitamini A, vitamini E, ferulic acid, resveratrol ndi zina zopangira mankhwala osamalira khungu; Nthawi zambiri amatha kudya zipatso ndi ndiwo zamasamba zowala kwambiri, monga tomato, tomato ali ndi lycopene yambiri.
Imatha kuyamwa mpweya wabwino ndikuletsa kupsinjika kwa okosijeni, mutha kudyanso broccoli, broccoli ili ndi chigawo chotchedwa mpiru mafuta glycosides, pambuyo potengera izi, zidzasungidwa pakhungu, kotero kuti maselo a khungu amatha kudziteteza. , zipatso ndi ndiwo zamasamba zimatha kulimbikitsa ma cell kukana kukalamba.
Chinthu chachitatu chofunika kwambiri pa ukalamba wa khungu
Khungu glycation
Glycation, mwamawu aukadaulo, amatchedwa non-enzymatic glycosylation reaction kapena Melad reaction. Mfundo ndi yakuti kuchepetsa shuga kumangiriza ku mapuloteni popanda ma enzyme; kuchepetsa shuga kumasinthidwa kwambiri ndi mapuloteni, ndipo kuchepetsa shuga ndi mapuloteni kumatenga nthawi yayitali okosijeni, dehydrogenation, ndi rearrangement reaction, zomwe zimapangitsa kuti pakhale zotsalira za glycosylation end-products, kapena AGEs mwachidule.
AGE ndi gulu la zinthu zosasinthika, zachikasu-bulauni, zomwe zimagwirizanitsidwa ndi tizilombo toyambitsa matenda zomwe siziwopa kuwonongeka kwa ma enzyme, ndipo ndi chimodzi mwa zifukwa zazikulu za ukalamba waumunthu. Tikamakalamba, ma AGE amadziunjikira m'thupi, zomwe zimapangitsa kuwonjezeka kwa kuuma kwa makoma amkati a mitsempha ya magazi, kusalinganika kwa mafupa a metabolism kumayambitsa matenda a osteoporosis, ndi kuwonongeka kwa collagen ndi elastin fibers mu dermis zomwe zimayambitsa kukalamba kwa khungu. Kukalamba kwapakhungu komwe kumachitika chifukwa cha glycation kumafotokozedwa mwachidule m'chiganizo chimodzi: shuga amawononga mapuloteni athanzi ndikusintha mapuloteni achichepere kukhala mapuloteni akale, zomwe zimapangitsa kukalamba komanso kutayika kwa collagen ndi ulusi wotanuka mu dermis.
Nthawi yotumiza: May-29-2024
