Epidermis youma imatanthawuza kuti chotchinga cha khungu chimasokonezeka, lipids amatayika, mapuloteni amachepetsedwa

Pambuyo pakuwonongeka kwakukulu kapena kosalekeza kwa chotchinga cha epidermal, njira yokonzanso khungu imafulumizitsa kupanga keratinocyte, kufupikitsa nthawi yolowa m'malo mwa maselo a epidermal, ndikuyimira kupanga ndi kutulutsidwa kwa ma cytokines, zomwe zimapangitsa hyperkeratosis ndi kutupa pang'ono kwa khungu. . Izi ndizofanana ndi zizindikiro za khungu louma.

Kutupa kwa m'deralo kungapangitsenso kuuma kwa khungu, makamaka, kuwonongeka kwa epidermal chotchinga kumalimbikitsa kaphatikizidwe ndi kutulutsidwa kwa ma cytokines oyambitsa kutupa, monga IL-1he TNF, kotero kuti maselo a chitetezo cha phagocytic, makamaka neutrophils, awonongeke. Pambuyo pokopeka ndi malo owuma, atafika komwe akupita, ma neutrophils amatulutsa leukocyte elastase, cathepsin G, protease 3, ndi collagenase m'magulu ozungulira, ndikupanga ndi kulemeretsa protease mu keratinocytes. Zotsatira zomwe zingachitike chifukwa cha kuchuluka kwa mapuloteni: 1. Kuwonongeka kwa ma cell; 2. Kutulutsidwa kwa ma cytokines oletsa kutupa; 3. Kuwonongeka msanga kwa ma cell-to-cell omwe amalimbikitsa ma cell mitosis. Proteolytic enzyme ntchito pakhungu louma, lomwe lingakhudzenso minyewa yamtundu wa epidermis, imalumikizidwa ndi pruritus ndi ululu. Kugwiritsa ntchito pamutu kwa tranexamic acid ndi α1-antitrypsin (protease inhibitor) ku xerosis ndikothandiza, kutanthauza kuti xeroderma imalumikizidwa ndi ntchito ya proteolytic enzyme.

Dry epidermis amatanthauza kutikhungu chotchinga chasokonezedwa, lipids amatayika, mapuloteni amachepa, ndipo zinthu zotupa zam'deralo zimatulutsidwa.Khungu kuuma chifukwa chotchinga kuwonongekandizosiyana ndi zouma zomwe zimayambitsidwa ndi kuchepa kwa sebum secretion, ndipo zotsatira za lipid supplementation zosavuta nthawi zambiri zimalephera kukwaniritsa zoyembekeza. Zodzoladzola zonyowa zomwe zimapangidwa kuti ziwonongeke zotchinga siziyenera kungowonjezera zinthu zonyowa za stratum corneum, monga ma ceramides, zinthu zachilengedwe zonyowa, ndi zina zotero, komanso kuganizira zotsatira za antioxidant, anti-inflammatory, ndi anti-cell division, motero kuchepetsa kusiyana kosakwanira. ma keratinocytes. Chotchinga khungu youma nthawi zambiri limodzi ndi pruritus, ndi Kuwonjezera antipruritic yogwira ayenera kuganiziridwa.