Khungu louma limatanthauza kuti chotchinga cha khungu chasokonekera, mafuta atayika, mapuloteni achepa

Pambuyo pa kuwonongeka kwadzidzidzi kapena kosatha kwa epidermal barrier, njira yokonzanso khungu mwadzidzidzi idzafulumizitsa kupanga ma keratinocyte, kufupikitsa nthawi yosinthira maselo a epidermal, ndikuyambitsa kupanga ndi kutulutsa ma cytokines, zomwe zimapangitsa kuti pakhale hyperkeratosis ndi kutupa pang'ono pakhungu. Izi zimachitikanso ndi zizindikiro za khungu louma.

Kutupa kwa m'deralo kungapangitsenso kuti khungu likhale louma, kwenikweni, kusweka kwa chotchinga cha epidermal kumalimbikitsa kupanga ndi kutulutsa ma cytokines angapo oyambitsa kutupa, monga IL-1he TNF, kotero kuti maselo oteteza thupi a phagocytic, makamaka ma neutrophils, amawonongeka. Pambuyo pokopeka ndi malo ouma, akafika komwe akupita, ma neutrophils amatulutsa leukocyte elastase, cathepsin G, protease 3, ndi collagenase m'maselo ozungulira, ndikupanga ndikuwonjezera protease mu keratinocytes. Zotsatira zomwe zingachitike chifukwa cha kuchuluka kwa protease: 1. Kuwonongeka kwa maselo; 2. Kutulutsidwa kwa ma cytokines oyambitsa kutupa; 3. Kuwonongeka msanga kwa kulumikizana kwa maselo ndi maselo komwe kumalimbikitsa mitosis ya maselo. Ntchito ya proteolytic enzyme pakhungu louma, yomwe ingakhudzenso mitsempha yomvera mu epidermis, imagwirizanitsidwa ndi pruritus ndi ululu. Kugwiritsa ntchito tranexamic acid ndi α1-antitrypsin (choletsa protease) pakhungu la xerosis ndikothandiza, zomwe zikusonyeza kuti xeroderma imagwirizana ndi ntchito ya proteolytic enzyme.

Khungu louma limatanthauza kutichotchinga cha khungu chasokonekera, mafuta amatayika, mapuloteni amachepa, ndipo zinthu zotupa za m'deralo zimatulutsidwa.Kuuma kwa khungu chifukwa cha kuwonongeka kwa zotchingandi yosiyana ndi kuuma komwe kumachitika chifukwa cha kuchepa kwa sebum secretion, ndipo zotsatira za lipid supplementation yosavuta nthawi zambiri sizimakwaniritsa zomwe zimayembekezeredwa. Zodzoladzola zonyowetsa zomwe zimapangidwa kuti ziwononge zotchinga siziyenera kungowonjezera zinthu zonyowetsa za stratum corneum, monga ceramides, zinthu zonyowetsa zachilengedwe, ndi zina zotero, komanso kuganizira zotsatira za antioxidant, anti-inflammatory, ndi anti-cell division, motero kuchepetsa kusiyana kosakwanira kwa keratinocytes. Kuuma kwa khungu lotchinga nthawi zambiri kumayenderana ndi pruritus, ndipo kuwonjezera kwa antipruritic actives kuyenera kuganiziridwa.