Epidermal structural and biochemical kusintha mu ukalamba wa khungu

Kagayidwe ka epidermis ndikuti ma basal keratinocyte amasunthira mmwamba pang'onopang'ono ndi kusiyanitsa kwa maselo, ndipo pamapeto pake amafa kuti apange stratum corneum yopanda nucleated, kenako ndikugwa. Ambiri amakhulupirira kuti ndi kukula kwa msinkhu, chigawo cha basal ndi spinous layer chimasokonezeka, mphambano ya epidermis ndi dermis imakhala yosalala, ndipo makulidwe a epidermis amachepa. Monga chotchinga chakunja cha thupi la munthu, epidermis imalumikizana mwachindunji ndi chilengedwe chakunja ndipo imakhudzidwa mosavuta ndi zinthu zosiyanasiyana zakunja. Kukalamba kwa epidermal kumawoneka mosavuta kutengera zaka komanso zinthu zakunja pa ukalamba wamunthu.

Mu epidermis ya ukalamba wa khungu, kusinthasintha kwa kukula, morphology ndi kuipitsidwa kwa maselo oyambira kumawonjezeka, kuphatikizika kwa epidermis ndi dermis pang'onopang'ono kumakhala lathyathyathya, msomali wa epidermal umakhala wosazama, ndipo makulidwe a epidermis amachepa. Kukula kwa epidermal kumachepa pafupifupi 6.4% pazaka khumi, ndipo kumacheperanso mwachangu mwa amayi. Epidermal makulidwe amachepetsa ndi zaka. Kusintha kumeneku kumawonekera kwambiri m'malo owonekera, kuphatikizapo mawonekedwe a nkhope, khosi, manja, ndi mapiko. Keratinocyte amasintha mawonekedwe akamakalamba khungu, kukhala lalifupi ndi kunenepa, pamene keratinocyte kukhala lalikulu chifukwa yochepa epidermal kusintha, nthawi kukonzanso ukalamba epidermis kumawonjezeka, ntchito proliferative wa epidermal maselo kuchepa, ndipo epidermis amakhala woonda. woonda, kuchititsa khungu kutaya elasticity ndi makwinya.

Chifukwa cha kusintha kwa kapangidwe kameneka, chigawo cha epidermis-dermis sichiri cholimba komanso chosatetezeka ku kuwonongeka kwa mphamvu yakunja. Kuchuluka kwa melanocyte kumachepa pang'onopang'ono pambuyo pa zaka 30, mphamvu yowonjezereka imachepa, ndipo ntchito ya enzymatic ya melanocytes imachepa pamlingo wa 8% -20% pazaka khumi. Ngakhale kuti khungu silosavuta kutenthedwa, ma melanocyte amakonda kuchulukirachulukira komweko kuti apange madontho a pigmentation, makamaka m'malo omwe ali ndi dzuwa. Maselo a Langerhans amachepetsedwa, zomwe zimapangitsa kuti chitetezo chamthupi chichepetse komanso kutengeka ndi matenda opatsirana.

Skin anlayzermakina amatha kugwiritsidwa ntchito kuzindikira makwinya akhungu, mawonekedwe, kutayika kwa collagen, ndi mawonekedwe a nkhope kuti athandizire kuzindikira kukalamba kwapakhungu.