Epidermal structural and biochemical kusintha mu ukalamba wa khungu

Kagayidwe ka epidermis ndikuti ma basal keratinocyte amapita pang'onopang'ono m'mwamba ndi kusiyanitsa kwa maselo, ndipo pamapeto pake amafa kuti apange non-nucleated stratum corneum, kenako ndikugwa.Nthawi zambiri amakhulupirira kuti ndi kukula kwa msinkhu, gawo la basal ndi spinous layer limasokonezeka, mphambano ya epidermis ndi dermis imakhala yosalala, ndipo makulidwe a epidermis amachepa.Monga chotchinga chakunja cha thupi la munthu, epidermis imalumikizana mwachindunji ndi chilengedwe chakunja ndipo imakhudzidwa mosavuta ndi zinthu zosiyanasiyana zakunja.Kukalamba kwa epidermal kumawoneka mosavuta kutengera zaka komanso zinthu zakunja pa ukalamba wamunthu.

Mu epidermis ya ukalamba wa khungu, kusinthasintha kwa kukula, morphology ndi zodetsa za maselo oyambira kumawonjezeka, mphambano ya epidermis ndi dermis pang'onopang'ono imakhala lathyathyathya, msomali wa epidermal umakhala wosazama, ndipo makulidwe a epidermis amachepa.Kukula kwa epidermal kumachepa pafupifupi 6.4% pazaka khumi, ndipo kumacheperanso mwachangu mwa amayi.Epidermal makulidwe amachepetsa ndi zaka.Kusintha kumeneku kumawonekera kwambiri m'malo owonekera, kuphatikizapo mawonekedwe a nkhope, khosi, manja, ndi mapiko.Ma Keratinocyte amasintha mawonekedwe akamakalamba khungu, kukhala lalifupi komanso kunenepa, pomwe keratinocyte imakula chifukwa cha kusintha kwaufupi kwa epidermal, nthawi yokonzanso ya epidermis yokalamba imakula, kuchuluka kwa epidermis kumachepa, ndipo epidermis imakhala yocheperako.woonda, kuchititsa khungu kutaya elasticity ndi makwinya.

Chifukwa cha kusintha kwa kapangidwe kameneka, chigawo cha epidermis-dermis sichiri cholimba komanso chosatetezeka ku kuwonongeka kwa mphamvu yakunja.Kuchuluka kwa melanocyte kumachepa pang'onopang'ono pambuyo pa zaka 30, mphamvu yowonjezereka imachepa, ndipo ntchito ya enzymatic ya melanocytes imachepa pamlingo wa 8% -20% pazaka khumi.Ngakhale kuti khungu silosavuta kutenthedwa, ma melanocyte amakonda kuchulukirachulukira komweko kuti apange madontho a pigmentation, makamaka m'malo omwe ali ndi dzuwa.Maselo a Langerhans amachepetsedwanso, zomwe zimapangitsa kuti chitetezo cha mthupi chichepetse komanso kutengeka ndi matenda opatsirana.

Skin choyatsiramakina amatha kugwiritsidwa ntchito kuzindikira makwinya akhungu, mawonekedwe, kutayika kwa collagen, ndi mawonekedwe a nkhope kuti athandizire kuzindikira kukalamba kwapakhungu.