Kukalamba kwa Khungu ——Kusamalira Khungu

Mahomoni amachepa ndi ukalamba, kuphatikizapo estrogen, testosterone, dehydroepiandrosterone sulfate, ndi hormone yokulira. Zotsatira za mahomoni pakhungu zimakhala zambiri, kuphatikizapo kuchuluka kwa collagen, makulidwe a khungu, komanso kuchuluka kwa madzi m'thupi. Pakati pawo, mphamvu ya estrogen ndi yodziwikiratu, koma momwe imakhudzira maselo sizikumveka bwino. Zotsatira za estrogen pakhungu zimawonekera makamaka kudzera mu keratinocytes ya epidermis, fibroblasts ndi melanocytes ya dermis, komanso maselo a tsitsi ndi ma sebaceous glands. Pamene luso la akazi lopanga estrogen limachepa, kukalamba kwa khungu kumawonjezeka. Kusowa kwa hormone estradiol kumachepetsa ntchito ya basal layer ya epidermis ndikuchepetsa kupanga collagen ndi ulusi wosalala, zonse zomwe ndizofunikira kuti khungu likhale lolimba. Kutsika kwa milingo ya estrogen pambuyo pa kusamba sikumangopangitsa kuti collagen ya pakhungu ichepe, komanso kagayidwe ka maselo a dermal kamakhudzidwa ndi kuchepa kwa estrogen pambuyo pa kusamba, ndipo kusinthaku kumatha kusinthidwa mwachangu pogwiritsa ntchito estrogen pamwamba. Kafukufuku watsimikizira kuti estrogen ya akazi imatha kuwonjezera collagen, kusunga makulidwe a khungu, ndikusunga chinyezi pakhungu ndi ntchito yotchinga ya stratum corneum mwa kuwonjezera acidic glycosaminoglycans ndi hyaluronic acid, kotero kuti khungu limakhalabe lolimba. Zikuoneka kuti kuchepa kwa ntchito ya endocrine ya thupi ndi chimodzi mwazinthu zofunika kwambiri zomwe zimapangitsa kuti khungu likalamba.

Kuchepa kwa kutulutsa kwa mahomoni a pituitary, adrenal, ndi gonads kumathandizira kusintha kwa khalidwe la thupi ndi khungu komanso machitidwe okhudzana ndi ukalamba. Kuchuluka kwa 17β-estradiol, dehydroepiandrosterone, progesterone, hormone ya kukula, ndi hormone yawo ya insulin growth factor (IGF)-I m'magazi a amuna kumachepa kwambiri, ndipo kuchepa kwa hormone m'magulu ena kumatha kuchitika akakula. Ma hormone amatha kukhudza mawonekedwe ndi ntchito ya khungu, kulowa kwa khungu, kuchira, cortical lipogenesis, ndi kagayidwe ka khungu. Chithandizo chobwezeretsa estrogen chingalepheretse kusamba komanso kukalamba kwa khungu.

——”Epiphysiology ya Khungu” Yinmao Dong, Laiji Ma, Chemical Industry Press

Choncho, pamene tikukula, chidwi chathu pa matenda a khungu chiyenera kuwonjezeka pang'onopang'ono. Tingagwiritse ntchito akatswiri ena.zida zowunikira khungukuwona ndi kulosera za siteji ya khungu, kulosera mavuto a khungu msanga, ndi kuthana nawo mwachangu.