Zodzoladzola Zoyera ndi Kagayidwe ka Utoto

Zodzoladzola Zoyera ndiUtotoKagayidwe kachakudya

Melanin anabolism imagawidwa m'magawo osiyanasiyana. Asayansi amakhulupirira kuti n'zotheka kuphunzira zinthu zoyeretsa thupi ndikugwira ntchito pa nthawi zosiyanasiyana za kagayidwe kachakudya.

(1) Gawo loyambirira la kupanga melanin

① Kusokoneza kulemba ndi/kapena glycosylation ya tyrosinase; ② Kuletsa owongolera kupanga tyrosinase; ③ Kulamulira tyrosinase pambuyo polemba.

(2) Nthawi yopangira Melanin
Monga enzyme yofunika kwambiri komanso enzyme yochepetsera liwiro la kupanga melanin, zoletsa tyrosinase ndiye njira yayikulu yofufuzira ndi chitukuko pakadali pano. Popeza zinthu zambiri zoyeretsa monga phenol ndi catechol derivatives zimafanana ndi tyrosine ndi dopa, zoyeretsa zomwe zawunikidwa nthawi zambiri zimagawidwa ngati zoletsa zosagwirizana kapena zopikisana za tyrosinase.

(3) Gawo lomaliza la kupanga melanin

①Amaletsa kusamutsa melanosome; zinthu zomwe zimakhala ndi mphamvu yoletsa serine protease, monga rwj-50353, zimapewa kwathunthu utoto wa epidermal womwe umachokera ku UBV; soybean trypsin inhibitor imakhala ndi mphamvu yoyera koma siikhudza poizoni wa maselo a pigment; Niacinamide, imatha kuletsa kufalikira kwa melanocytes pakati pa melanocytes ndi keratinocytes; ② Kufalikira ndi kagayidwe ka Melanin, α-hydroxy acid, free fatty acid ndi retinoic acid, zimathandizira kukonzanso maselo ndikulimbikitsa kuchotsa melatinocytes.

Ndikofunika kudziwa kuti kafukufuku ndi kugwiritsa ntchito zinthu zoyera zochokera pa kagayidwe ka melanin komwe kali pamwambapa sikoyenera kupewa ndi kuchiza ma senile plaques. Popeza njira yopangira ma senile plaques ikugwirizana ndi kapangidwe ka lipofuscin, zinthu zotsutsana ndi okosijeni zimagwiritsidwa ntchito nthawi zambiri kuchedwetsa ndikusintha ma senile plaques.